A rare inherited arrhythmia syndrome in which the heart’s structure is normal but certain triggers — particularly physical exertion or emotional stress — can provoke dangerous ventricular arrhythmias, including polymorphic ventricular tachycardia. CPVT is caused by mutations affecting calcium regulation within heart cells, most commonly in the RYR2 gene. It typically presents in childhood or adolescence and can cause sudden cardiac arrest. Treatment includes beta-blockers, lifestyle modification (avoidance of competitive sport), and often an ICD. Family screening is essential following diagnosis.
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