Atorvastatin is a statin medication that lowers LDL (low-density lipoprotein) cholesterol and total cholesterol by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol production in the liver. Reducing LDL cholesterol slows the progression of atherosclerotic plaques in the coronary arteries and significantly reduces the risk of heart attack, stroke, and cardiovascular death.
Atorvastatin is commonly prescribed to cardiac arrest survivors whose event was caused by coronary artery disease, as part of [secondary prevention](/glossary/secondary-prevention/). High-intensity atorvastatin (typically 80mg daily) is recommended for people at very high cardiovascular risk, in line with NICE guidelines. It may also reduce arterial inflammation independently of its cholesterol-lowering effect.
Atorvastatin is taken once daily, usually at night. Common side effects include muscle aches (myalgia). In rare cases, more serious muscle inflammation (myositis or rhabdomyolysis) can occur and requires prompt medical assessment. Atorvastatin should not be taken with grapefruit juice, as grapefruit significantly increases drug levels. Liver function may be monitored periodically. If you experience unexplained muscle pain or weakness while taking atorvastatin, contact your GP or [Cardiac Nurse Specialist](/glossary/cardiac-nurse-specialist/).
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