Brugada Syndrome

A genetic heart condition in which the electrical system of the heart malfunctions despite the heart’s structure appearing normal. Caused by mutations in the SCN5A gene (which controls sodium channels in heart cells), Brugada syndrome produces a characteristic pattern on an ECG and predisposes affected individuals to potentially fatal ventricular arrhythmias, most often at rest or during sleep. It is more common in men and in those of South-East Asian descent. An ICD is the main treatment for those considered at high risk. Brugada syndrome is inherited and family screening is recommended following diagnosis.